Srila Srinivasa Acarya's parents were present when Lord Caitanya Mahaprabhu accepted sannyasa, the renounced order of life. Soon after that, they traveled from their village in Bengal to Jagannatha Puri to visit Lord Caitanya, who told them that they would have a son who would be empowered to spread the teachings of the Rupa Gosvami and Sanatana Gosvami, two of Lord Caitanya's foremost disciples.

Srinivasa was absorbed in Krsna consciousness from an early age. In his youth he traveled to Jagannatha Puri. There, Lord Caitanya having returned to the spiritual world, Srinivasa met many of the Lord's intimate associates. Srinivasa returned to Bengal but soon left for Vrndavana, where he accepted Gopala Bhatta Gosvami as his spiritual master. Under the care of Jiva Gosvami, Srinivasa learned the complete teachings of Lord Caitanya.

Along with Syamananda Pandita and Narottama Dasa Thakura, Srinivasa Acarya carried the writings of the Gosvamis to Bengal and Orissa. Srinivasa initiated many disciples and wrote devotional songs, including Sri Sad-gosvamy-astakam, eight prayers glorifying the six Gosvamis of Vrndavana.