Srila Madhu Pandita Gosvami was a disciple of Srila Gadadhara Pandita, one of Lord Caitanya's principal associates. Madhu Pandita worshiped the Krsna Deity in Vrndavana known as Gopinatha, who had originally been installed by Vajranabha, Lord Krsna's great-grandson.

Madhu Pandita was present when Narottama, Syamananda, and Srinivasa left Vrndavana to carry the writings of the Gosvamis to Bengal. He blessed Srinivasa by garlanding him with a flower garland that had been worn by Lord Gopinatha.